Guardant Health Co-CEO Exercises RSUs with Routine Tax Withholding

Executive Summary

On October 2, 2026, Guardant Health, Inc. ($GH) filed a Form 4 for Co-Chief Executive Officer and Director AmirAli Talasaz. The filing reports the settlement of multiple tranches of Restricted Stock Units (RSUs) on September 30 and October 1, 2026, totaling 36,530 shares acquired at zero cost. To satisfy associated tax withholding obligations, 18,515 shares were retained by the company at prices of $178.36 and $174.75 per share, representing an aggregate tax payment value of approximately $3,240,651.33.

Transaction Breakdown

• 2026-09-30:
  • RSU Vesting (Code M): Acquired 2,817 shares of Common Stock at $0.00.
  • Tax Withholding (Code F): Disposed of 1,428 shares at $178.36 per share ($254,698.08).
• 2026-10-01:
  • RSU Vesting (Code M): Acquired 23,997 shares and 9,716 shares (totaling 33,713 shares) at $0.00.
  • Tax Withholding (Code F): Disposed of 17,087 shares at $174.75 per share ($2,985,953.25).
• Net Change: Net addition of 18,015 common shares.

Ownership Structure & Significance

• Nature of Ownership: Indirect, held through the Talasaz and Eskandari 2017 Family Trust. Following these transactions, the trust holds 1,842,366 shares of Guardant Health Common Stock.
• Significance: Low. The transactions represent scheduled quarterly vestings under preexisting equity compensation awards (granted in March 2024, March 2025, and March 2026). The dispositions were mandatory withholdings solely to satisfy tax obligations (Code F) rather than discretionary open-market sales.