Revolution Medicines COO Margaret A. Horn Disposes of Shares for Tax Obligations via Rule 10b5-1 Plan

Executive Summary

On September 18, 2026, Margaret A. Horn, Chief Operating Officer of Revolution Medicines, Inc. ($RVMD), filed a Form 4 disclosing the sale of 4,967 shares of Common Stock executed on September 16, 2026. The combined value of the sales totaled approximately $989,612.58 at a volume-weighted average price of ~$199.24 per share.

Transaction Breakdown

1. Block 1: 76 shares sold at a weighted average price of $195.0083 (range: $195.00 to $195.03).
2. Block 2: 4,891 shares sold at $199.3032.

Following these dispositions, Horn continues to directly hold 149,680 shares, which includes 56,713 restricted stock units (RSUs).

Context and Analysis

• Nature of Trade: As indicated in the footnotes, the transactions were executed pursuant to a Rule 10b5-1 instruction letter established on May 31, 2023, designed specifically to satisfy tax withholding obligations triggered by RSU vestings.
• Significance: Because the trade was pre-planned, non-discretionary, and executed purely to fulfill tax liabilities, it does not indicate a shift in insider sentiment or confidence regarding the company's operating outlook.