SEC Filing Analysis: Annovis Bio, Inc. (ANVS)

Executive Summary

• Trading Significance: Low
• Key Takeaway: A director made a small, routine open-market purchase, slightly increasing an already substantial ownership position.
• Market Impact: The transaction is too small (0.05% of market cap) to have a meaningful market impact.

Company Information

Field	Value
Company	Annovis Bio, Inc.
Ticker Symbol	ANVS
CIK	0001477845
Industry	PHARMACEUTICAL PREPARATIONS

Insider Information

Field	Value
Name	Hoffman Michael B
CIK	0001290208
Title/Position	null
Relationship	Director

Transaction Details

Field	Value
Form Type	4
Transaction Date	2025-11-14
Transaction Code	P (Open market or private purchase)
Security Type	Common Stock
Shares Involved	15,000
Price Per Share	$2.11
Total Value	$31,650
Shares Owned After	2,470,539 (Directly)
Ownership Type	Direct

Financial Impact Assessment

Transaction Materiality

Metric	Value
Transaction Value	$31,650
% of Market Cap	0.053%
Shares Transacted	15,000
% of Shares Outstanding	0.077%
Post-Transaction Ownership	2,693,906 shares (13.83% of outstanding, including indirect holdings)
Materiality Assessment	Low

Impact Evaluation

• Market Cap Context: For a company with a $60 million market capitalization, this $31,650 transaction is minor and does not represent a significant capital allocation by the insider.
• Ownership Concentration: The key point of interest is not the transaction itself, but the insider's total post-transaction ownership. Holding over 13% of the company's outstanding shares indicates a very strong alignment with shareholder interests.
• Transaction Significance: The purchase is not material in terms of size, representing a negligible percentage of both market cap and shares outstanding. Its significance is low.

Additional Context

Transaction Notes

• Footnotes: The filing notes an additional 223,357 shares held indirectly through 'The 2018 Jane and Michael Hoffman Descendants Trust', over which the reporting person has voting and investment power. This brings total beneficial ownership to 2,693,906 shares.